Medical Pharmacology and Therapeutics

SECTION 1 General principles 1. Principles of pharmacology and mechanisms of drug action 2. Pharmacokinetics 3. Drug discovery, safety and efficacy 4. The nervous system, neurotransmission and the peripheral autonomic nervous system SECTION 2 The cardiovascular system 5. Ischaemic heart disease 6. Systemic and pulmonary hypertension 7. Heart failure 8. Cardiac arrhythmias 9. Cerebrovascular disease and dementia 10. Peripheral vascular disease 11. Haemostasis SECTION 3 The respiratory system 12. Asthma and chronic obstructive pulmonary disease 13. Respiratory disorders: cough, respiratory stimulants, cystic fibrosis and neonatal respiratory distress syndrome SECTION 4 The renal system 14. Diuretics 15. Disorders of micturition 16. Erectile dysfunction SECTION 5 The nervous system 17. General anaesthetics 18. Local anaesthetics 19. Opioid analgesics and the management of pain 20. Anxiolytics, sedatives and hypnotics 21. The major psychotic disorders: schizophrenia and mania 22. Depression, attention deficit hyperactivity disorder and narcolepsy 23. Epilepsy 24. Extrapyramidal movement disorders and spasticity 25. Other neurological disorders: multiple sclerosis, motor neuron disease and Guillain-Barre syndrome 26. Migraine SECTION 6 The musculoskeletal system 27. The neuromuscular junction and neuromuscular blockade 28. Myasthenia gravis 29. Non-steroidal anti-inflammatory drugs 30. Rheumatoid arthritis, other inflammatory arthritides and osteoarthritis 31. Hyperuricaemia and gout SECTION 7 The gastrointestinal system 32. Nausea and vomiting 33. Dyspepsia and peptic ulcer disease 34. Inflammatory bowel disease 35. Constipation, diarrhoea and irritable bowel syndrome 36. Liver disease 37. Obesity SECTION 8 The immune system 38. The immune response and immunosuppressant drugs 39. Antihistamines and allergic disease SECTION 9 The endocrine system and metabolism 40. Diabetes mellitus 41. The thyroid and control of metabolic rate 42. Calcium metabolism and metabolic bone disease 43. Pituitary and hypothalamic hormones 44. Corticosteroids (glucocorticoids and mineralocorticoids) 45. Female reproduction 46. Androgens and anabolic steroids 47. Anaemia and haematopoietic colony-stimulating factors 48. Lipid disorders SECTION 10 The skin and eyes 49. Skin disorders 50. The eye SECTION 11 Chemotherapy 51. Chemotherapy of infections 52. Chemotherapy of malignancy SECTION 12 General features: toxicity and prescribing 53. Drug toxicity and overdose 54. Substance abuse and dependence 55. Prescribing, adherence and information about medicines 56. Drug therapy in special situations Index